Consciousness is seen as a difficult “binding” problem. Binding, a process where different sensations evoked by an item are associated in the nervous system, can be viewed as a process similar to associative learning. Several reports that consciousness is associated with some form of memory imply that different forms of memories have a common feature contributing to consciousness. Based on a proposed synaptic mechanism capable of explaining different forms of memory, we developed a framework for consciousness. It is based on (...) the formation of semblance of sensory stimulus from (1) synaptic semblances when excitatory postsynaptic potentials arrive at functionally LINKed postsynaptic membranes, and (2) network semblances when these potentials summate to elicit action potential initiating activity in a network of neurons. It is then possible to derive a framework for consciousness as a multi-dimensional semblance. According to this framework, a continuum of semblances formed from background sensory stimuli and oscillating neuronal activities serve to maintain consciousness. Feasibility of this framework to explain various physiological and pathological states of consciousness, its subjective nature and qualia is examined. (shrink)

Consciousness is seen as a difficult “binding” problem. Binding, a process where different sensations evoked by an item are associated in the nervous system, can be viewed as a process similar to associative learning. Several reports that consciousness is associated with some form of memory imply that different forms of memories have a common feature contributing to consciousness. Based on a proposed synaptic mechanism capable of explaining different forms of memory, we developed a framework for consciousness. It is based on (...) the formation of semblance of sensory stimulus from (1) synaptic semblances when excitatory postsynaptic potentials arrive at functionally LINKed postsynaptic membranes, and (2) network semblances when these potentials summate to elicit action potential initiating activity in a network of neurons. It is then possible to derive a framework for consciousness as a multi-dimensional semblance. According to this framework, a continuum of semblances formed from background sensory stimuli and oscillating neuronal activities serve to maintain consciousness. Feasibility of this framework to explain various physiological and pathological states of consciousness, its subjective nature and qualia is examined. (shrink)

Different anesthetics are known to modulate different types of membrane-bound receptors. Their common mechanism of action is expected to alter the mechanism for consciousness. Consciousness is hypothesized as the integral of all the units of internal sensations induced by reactivation of inter-postsynaptic membrane functional LINKs during mechanisms that lead to oscillating potentials. The thermodynamics of the spontaneous lateral curvature of lipid membranes induced by lipophilic anesthetics can lead to the formation of non-specific inter-postsynaptic membrane functional LINKs by different mechanisms. These (...) include direct membrane contact by excluding the inter-membrane hydrophilic region and readily reversible partial membrane hemifusion. The constant reorganization of the lipid membranes at the lateral edges of the postsynaptic terminals (dendritic spines) resulting from AMPA receptor-subunit vesicle exocytosis and endocytosis can favor the effect of anesthetic molecules on lipid membranes at this location. Induction of a large number of non-specific LINKs can alter the conformation of the integral of the units of internal sensations that maintain consciousness. Anesthetic requirement is reduced in the presence of dopamine that causes enlargement of dendritic spines. Externally applied pressure can transduce from the middle ear through the perilymph, cerebrospinal fluid, and the recently discovered glymphatic pathway to the extracellular matrix space, and finally to the paravenular space. The pressure gradient reduce solubility and displace anesthetic molecules from the membranes into the paravenular space, explaining the pressure reversal of anesthesia. Changes in membrane composition and the conversion of membrane hemifusion to fusion due to defects in the checkpoint mechanisms can lead to cytoplasmic content mixing between neurons and cause neurodegenerative changes. The common mechanism of anesthetics presented here can operate along with the known specific actions of different anesthetics. (shrink)

Unlike other organs that operate continuously, such as the heart and kidneys, many of the operations of the nervous system shut down during sleep. The evolutionarily conserved unconscious state of sleep that puts animals at risk from predators indicates that it is an indispensable integral part of systems operation. A reasonable expectation is that any hypothesis for the mechanism of the nervous system functions should be able to provide an explanation for sleep. In this regard, the semblance hypothesis is examined. (...) Postsynaptic membranes are continuously being depolarized by the quantally released neurotransmitter molecules arriving from their presynaptic terminals. In this context, an incidental lateral activation of the postsynaptic membrane is expected to induce a semblance (cellular hallucination of arrival of activity from its presynaptic terminal, which forms a unit for internal sensation) of the arrival of activity from its presynaptic terminal as a systems property. This restricts induction of semblance to a context of a very high ratio of the duration of the default state of neurotransmitter-induced postsynaptic depolarization to the total duration of incidental lateral activations of the postsynaptic membrane. This requirement spans within a time-bin of a few sleep-wake cycles. Since the duration of quantal release remains maximized, the above requirement can be achieved only by ceiling the total duration of incidental lateral activations of the postsynaptic membrane, which necessitates a state of sleep. (shrink)

Perception is a first-person internal sensation induced within the nervous system at the time of arrival of sensory stimuli from objects in the environment. Lack of access to the first-person properties has limited viewing perception as an emergent property and it is currently being studied using third-person observed findings from various levels. One feasible approach to understand its mechanism is to build a hypothesis for the specific conditions and required circuit features of the nodal points where the mechanistic operation of (...) perception take place for one type of sensation in one species and to verify it for the presence of comparable circuit properties for perceiving a different sensation in a different species. The present work explains visual perception in mammalian nervous system from a first-person frame of reference and provides explanations for the homogeneity of perception of visual stimuli above flicker fusion frequency, the perception of objects at locations different from their actual position, the smooth pursuit and saccadic eye movements, the perception of object borders, and perception of pressure phosphenes. Using results from temporal resolution studies and the known details of visual cortical circuitry, explanations are provided for (a) the perception of rapidly changing visual stimuli, (b) how the perception of objects occurs in the correct orientation even though, according to the third-person view, activity from the visual stimulus reaches the cortices in an inverted manner and (c) the functional significance of well-conserved columnar organization of the visual cortex. A comparable circuitry detected in a different nervous system in a remote species-the olfactory circuitry of the fruit fly Drosophila melanogaster-provides an opportunity to explore circuit functions using genetic manipulations, which, along with high-resolution microscopic techniques and lipid membrane interaction studies, will be able to verify the structure-function details of the presented mechanism of perception. (shrink)

Discipleship is a responsibility of the Church. It is an outlet in which the regeneration of Church leadership to the younger generation is conducted. Before the COVID-19 pandemic, discipleship and mentoring of youth leaders, especially key persons of GKII (Gereja Kemah Injil Indonesia) youth were provided by means of in-person activities. During the pandemic, digital media has been utilised for various church activities, including mentoring these key persons. Hence, this research intends to explore: (1) the method by which key persons (...) practise digital discipleship and (2) the benefits of digital media in youth discipleship to facilitate faith growth. This research is a qualitative research. Data were collected by means of interviews and observations on several key persons’ digital media accounts. The research shows that social media significantly benefits the discipleship process. It was found that digital discipleship was quite often carried out during the pandemic, especially in urban areas, with WhatsApp and Zoom meetings as its two primary means. However, it slightly declined along with the lifting of social gathering restrictions. The main themes explored in the mentoring sessions were discipleship, soteriology, spiritual life, motivational and digital media materials, and youth ministry in the digital era. The discipleship practice used was the NM-SM (Nurtured, Matured, Served, Mission) pattern.Contribution: The results of this research contribute to the development of knowledge, especially in the field of youth discipleship, and digital media-based discipleship. This research also shows that digital media has become an effective theological space during the pandemic and post-pandemic periods. (shrink)

The newly updated Right and Wrong 2nd Edition is an accessible introduction to the major traditions in western philosophical ethics, written in a lively and engaging style. It is designed for entry-level ethics courses and includes real-life ethical scenarios chosen to appeal directly to students. Greatly expanded and improved, this successful text introduces students to the major ethical traditions, and provides a simple methodology for resolving ethical dilemmas Treats teleological and deontological approaches to ethics as the two most important traditions, (...) but now includes chapters on virtue ethics and the ethics of care The very accessible writing style speaks directly to students’ own experience Draws examples from three types of real-life ethical scenarios submitted by students: academic dishonesty, partying, and personal relationships Provides a concise treatment of this notoriously complex subject, perfect for entry-level ethics and applied ethics courses. (shrink)

This chapter contains section titled: Personhood: A Start Are Dolphins Persons? Language and the Hand Personhood Redefined Conclusion: What Kind of Beings Are Dolphins?

Collected works of Dngul-chu Dbyangs-can-grub-paʼi-rdo-rje, 1809-1887 on Tibetan Buddhist doctrines, philosophy, and rituals of Dge-lugs-pa.

This chapter contains section titled: Human Adaptations to the Water: An Exercise in Imagination Life in the ocean: the importance of other people Dolphin Intelligence in the Wild Dolphin Communication Social Intelligence and Group Cohesion Dolphins and Sex The Cognitive and Affective Skills Involved in Group Living Conclusion: Dolphin Intelligence.

This chapter contains section titled: “Human” Versus “Person” Human, Person and Ethics Philosophical Ethics Ethics and Nonhumans “Alien Intelligence” Two Questions.

This chapter contains section titled: “Interspecies ethics” The Dolphin/Tuna Controversy Dolphins in Captivity So What Do We Do? The Ethics of Human/Dolphin Contact: Two Final Thoughts.

The text of Kant’s first dissertation is a translation from Latin from an academic publication of a collection of Kant’s works: Kant, I. Meditationum quarundam de igne succincta delineatio... In: Königlich Preußischen Akademie der Wissenschaften, ed., 1910. Kants Gesammelte Schriften. 1. Abhandling: Werke. Band I: Vorkritische Schriften I, 1747-1756. Berlin: Georg Reimer, 1910, pp. 369-384. The publication is available at https://korpora.zim.uni-duisburg- essen.de/kant/aa01/ [Accessed 10 March 2019]. Pagination and illustrations are from the same publication, the page numbers are in square brackets (...) at the beginning of the page. Page footnotes, if indicated, draw on the commentaries of Lewis White Beck, the translator of the dissertation into English from the following edition: Kant, I., 2012. Natur­al Science, edited by E. Watkins, translated by L. W. Beck, J. B. Edwards, O. Reinhardt, M. Schönfeld and E. Watkins. Cambridge: Cambridge University Press, pp. 713-714. It was important for the translator to follow the course of Kant’s thought and as far as possible preserve his style, including recurring words. Natural science terminology keeps as close as possible to the dissertation text, so instead of the term “gas”, which Kant does not use, the translator resorts to a loan-translation “elastic liquid,” harking back to the Russian term упругая жидкость which was proposed by Mikhail V. Lomonosov but did not catch on. For the same reason the translator uses the loan translation “moment” instead of the more common “motive force”. “Gradus”, however, is always translated as “degree” for the sake of uniformity. All the translator’s additions to the Kantian text are within square brackets. When the meaning of a word is translated in a form that departs from the original meaning due to context the Latin original is attached within round brackets in the grammatical form used by Kant. To facilitate understanding, long compound sentences of the Kantian text are sometimes broken up into several simple sentences. The structure of the text and title page format have been preserved. The translator would like to express sincere gratitude to Alexei N. Krouglov and Svyatopolk N. Yeschenko for their valuable advice, remarks and help and support in preparing this publication. (shrink)

Analysis of various Buddhist philosophical views.

For courses in Business Ethics A fresh approach to the assumptions that underlie business practices Two recent events — the 2008 economic meltdown and the ongoing concentration of the nation's wealth in the hands of a very small percentage of the population — have led many people to question a number of basic assumptions about business, corporations, and the workings of contemporary free-market capitalism in a global economy. Written as a dialogue between Socrates and a hypothetical contemporary CEO,Socrates Comes to (...) Wall Street leads students to think critically about perspectives and practices that are taken as “givens” in most American business schools and corporations. Employing this original and provocative approach, author Thomas White seeks to encourage the next generation of business leaders to be more astute about the implications of their actions, and to act more prudently and more fairly than we have seen in the recent past. (shrink)